The Colts are desperate at quarterback, with one out for the season and the other with uncertain availability for NFL Week 15.

Following Sunday's latest loss to the Jacksonville Jaguars, the Colts are now 8-5 and are the eighth seed in the AFC -- one spot out of a playoff spot at the moment. The Houston Texans are also 8-5 but hold the playoff tie-breaker over the Colts, having won the head-to-head matchup. These two teams will meet again later this season.

Just when Colts fans thought they had endured enough rollercoaster emotions for one season, the football gods decided to throw another wrench into the gears.

The Jacksonville Jaguars play the Indianapolis Colts in Week 14 of the 2025 NFL season. Who wins? See our predictions and picks, plus game odds.

The Jacksonville Jaguars face the Indianapolis Colts in NFL Week 14 with first place in the AFC South on the line. Follow our live updates.

The Jaguars beat the Colts for their fourth straight win, while Indianapolis' playoff hopes are in jeopardy after a third straight loss.

Kenny Moore II has been nominated by the Indianapolis Colts once again for the Walter Payton Man of the Year award.

The Jacksonville Jaguars and Indianapolis Colts will play their 49th and 50th games against each other in December, starting Dec. 7 in Jacksonville.