The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games.

The Tennessee Titans say the home of defensive tackle Jeffery Simmons was burglarized while he was on the road in San Francisco.

Trent Williams successor in PFF's 2026 mock draft—Utah's Caleb Lomu—bolstering protection for Brock Purdy and the offensive line.

A 10-4 record keeps the 49ers in the thick of a wild NFC playoff race and moved their win streak to four games. The Titans figure to end the year with one of the worst records in the NFL, so Sunday's game wasn't a great indicator of where the 49ers stand in the NFL hierarchy. However, it did provide plenty to learn and take away.

Yesterday, Levi’s Stadium was electric again as the San Francisco 49ers flexed their offensive muscles in front of their home crowd. The 49ers’ game against the Tennessee Titans lived up to the hype for those hungry for scoring and big plays.

Philip Rivers came out of retirement to help the Indianapolis Colts reach the postseason, and he held his own in the 18-16 loss to the Seattle Seahawks. While CBS Sports' Matt Zenitz reported that Anthony Richardson is medically cleared to return to the field, the Colts will not make a change at quarterback.

Although nothing seems to have gone well for the 49ers this season, San Francisco still is in good shape to make a run in the 2025 NFL playoffs.

The Jets trade up for quarterback Fernando Mendoza, who ranks fifth among FBS quarterbacks in PFF passing grade (90.5) and leads the nation with

Quarterback Philip Rivers came out of retirement and was signed to the Colts 53-man roster on Saturday. Will he play today against the Seahawks?