The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...

For a cell to progress through the G1 phase of the cell cycle and divide, it must first integrate various signals. It emerges that cells in a ‘primed’ G1 state — characterized by intermediate ...

DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...