Nature

Clinical application of array-based comparative genomic hybridization to define the relationship between multiple synchronous tumors

Comparative genomic hybridization (CGH) is a technique that has greatly facilitated detection of gains and losses in DNA copy number, and has been of particular utility in elucidating the pattern of ...
Nature

Array-CGH fine mapping of minor and cryptic HR-CGH detected genomic imbalances in 80 out of 590 patients with abnormal development

In our laboratory, we have used HR-CGH as a screening method for cryptic chromosomal imbalances for several years. In an initial study, we found a cryptic chromosomal imbalance in 5 out of 50 patients ...
GEN

Harnessing the Promise of Array CGH

In addition to the surprising revelation that our chromosomes harbor fewer genes than originally predicted, the Human Genome Project also unveiled that all individuals share approximately 99.9% of ...
GEN

Solutions for DNA Copy-Number Analysis

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...