This study aimed to include those disorders that influence the clinical management of patients and used clinician chart review to do so. By means of a practice-based analysis of individual patient ...

The control of biochemical fluxes is distributed, and to perturb complex intracellular networks effectively it is often necessary to modulate several steps simultaneously. However, the number of ...

Background Most evidence on chronic diseases has been collected for single diseases whereas in reality, patients often suffer from more than one condition. There is a growing need for evidence-based ...