When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example, DNA damage ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres—the protective ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...

A new study demonstrates that replicative senescence depends upon ATM kinase, and that high oxygen generates a hyperactive ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in ...

Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial ...