A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break-when both sides of the DNA helix are cut at once.

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

Small, cancer-associated DNA circles "hitchhike" on chromosomes during cell division to spread efficiently to daughter cells ...

Researchers discovered that stiff DNA segments inside nucleosomes physically block chromatin remodeling. The remodeling ...

Within the nucleus of every cell are long strings of DNA, the code that holds all the information needed to make and control every cell within a living organism. DNA, which stands for deoxyribonucleic ...

On 22 May 2019, scientists from Queen's University boarded a modified Falcon 20 aircraft at Ottawa airport. Scheduled was a ‘vomit comet’ flight, where the plane repeatedly climbs to 8km in a steep ...

A new study has illuminated an important process that occurs during cell division and is a likely source of DNA damage under some circumstances, including cancer. A new study from scientists at the ...