When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key ...

Inside every human cell, six feet of DNA folds into a nucleus that is only a few micrometers wide, yet still manages to ...

Researchers discovered that stiff DNA segments inside nucleosomes physically block chromatin remodeling. The remodeling machinery normally shifts DNA by creating 20–30 base-pair loops, but these ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...

Fluorogenic DNA aptamers produce light only in the correct structural state, enabling programmable molecular logic, ...

Cancer isn't just about broken genes—it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in ...

A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable ...

When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key repair process called homologous recombination, the cell uses loops in its ...