Nature

Endonuclease V cleaves at inosines in RNA

RNA editing covalently alter the nucleotide sequence of RNA transcripts relative to that of the encoding DNA, thereby contributing to gene diversity 1. One of the most prevalent RNA modifications is ...
PNAS

Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer

Homing endonuclease genes are “selfish” mobile genetic elements whose endonuclease promotes the spread of its own gene by creating a break at a specific target site and using the host machinery to ...
Nature

Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor

Homing endonucleases are usually encoded within self-splicing introns or inteins, and are found in representatives of all three kingdoms 1,2. The endonuclease genes and their host intron or intein are ...
Europe PMC

Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase.

The influenza A polymerase is a heterotrimer which transcribes viral mRNAs and replicates the viral genome. To initiate synthesis of mRNA, the polymerase binds a host pre-mRNA and cleaves a short ...
The EMBO Journal

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

Restarting stalled replication forks partly depends on the break‐induced recombination pathway, in which a DNA double‐stranded break (DSB) is created on the stalled replication fork to initiate the ...
The EMBO Journal

Structure of a trapped endonuclease III–DNA covalent intermediate

Nearly all cells express proteins that confer resistance to the mutagenic effects of oxidative DNA damage. The primary defense against the toxicity of oxidative nucleobase lesions in DNA is the ...
PNAS

The heteromeric Nanoarchaeum equitans splicing endonuclease cleaves noncanonical bulge–helix–bulge motifs of joined tRNA halves

Schematic representation of cis- and trans-splicing of N. equitans tRNAs. During conventional tRNA cis-splicing, the archaeal splicing machinery recognizes and cleaves a BHB motif in the pre-tRNA, ...
C&EN

Mutational Analysis of Endonuclease V from Thermotoga maritima

Department of Microbiology and Immunology, Hearst Microbiology Research Center and Strang Cancer Prevention Center, The Joan and Sanford I. Weill Medical College of Cornell University, 1300 York ...
Frontiers

Characterization of winged helix domain fusion endonucleases as N6-methyladenine-dependent type IV restriction systems

Winged helix (wH) domains, also termed winged helix-turn-helix (wHTH) domains, are widespread in all kingdoms of life and have diverse roles. In the context of DNA binding and DNA modification sensing ...
Frontiers

Activity of Human Apurinic/Apyrimidinic Endonuclease APE1 Toward Damaged DNA and Native RNA With Non-canonical Structures

1 Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Novosibirsk, Russia 2 Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia The primary role of ...
Europe PMC

Endonuclease V cleaves at inosines in RNA.

Endonuclease V orthologues are highly conserved proteins found in all kingdoms of life. While the prokaryotic enzymes are DNA repair proteins for removal of deaminated adenosine (inosine) from the ...