Because glucuronyl transferase catalyzes the conjugation of bilirubin, a deficiency of the enzyme in newborn infants can result in jaundice. Another consequence of this deficiency is an increased ...

In this study, the duration of enzyme induction provoked by unlabelled lactose ureide (LU) in orocaecal transit time (OCTT) measurements with lactose-[13 C]ureide (13 C-LU) was evaluated. Without ...

Induction of cytochrome P450 (CYP) by drugs is one of major concerns for drug-drug interactions. Thus, the assessment of CYP induction by novel compounds is a vital component in the drug discovery and ...

A white female infant had first been noted to be jaundiced shortly after birth. She was the product of an uncomplicated pregnancy in a 21-year-old gravida 3, para 2. The birth weight was 3.45 kg.

The cytochromes P450 (CYPs) are the main enzyme family for metabolism of therapeutic drugs. CYP3A4 is the most active drug metabolizing CYP, and it plays a prominent role in adverse drug-drug ...

Phase I study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases: A pharmacokinetic (PK)-pharmacodynamic (PD) study to identify the optimal therapeutic dose ...

Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...

The interaction between Botrytis cinerea Pers. and grapevine (Vitis vinifera L.) was studied in a model system of reduced complexity. Cultured plant cells and fragments of fungal cell wall were used ...

Enzymes help with specific functions that are vital to the operation and overall health of the body. They help speed up chemical reactions in the human body. They are essential for respiration, ...

Researchers Explore a Number of Strategies to Better Predict Drug Responses in the Clinic As drug development costs continue to escalate, determining toxicity and possible interactions with foods, ...