While the genus antibody claim was effectively killed by the U.S. Supreme Court in Amgen v. Sanofi, it lives on in Europe despite a few recent setbacks at the European Patent Office ("EPO") and the ...

The novel Epitope Binning-seq technology streamlines antibody epitope mapping and enables the simultaneous evaluation of large numbers of genetically encoded antibodies, grouping them into distinct ...

This article is based on a poster originally authored by Sophie Snow, Kira Freeman, Zaynab Isseljee, Alice Brankin and Christine Sanfelice, which was presented at ELRIG Drug Discovery 2024 in ...

In a recent study posted to the bioRxiv* preprint server, researchers designed an efficient vaccine design against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Study: ...

CAR-T cell therapies have been heralded as a game changer for blood cancers, but those therapies approved so far have been focused on a few subtypes of leukemia, lymphoma and myeloma. Now, a new ...

The early identification of antibody candidates with desired affinities and dissociation kinetics, binding epitopes and critical quality attributes is vital for avoiding later-phase failures caused by ...

New research shows that engineering epitopes on donor hematopoietic stem and progenitor cells (HSPCs) used in bone marrow transplants can give hematopoietic lineages selective resistance to monoclonal ...

Monoclonal antibodies (mAbs) are one of the most successful therapeutic drug classes, generating lucrative sales for the pharmaceutical industry. In 2016, more than 20 therapeutic antibodies gained ...

Epitope binning is an important step towards selecting the best monoclonal antibody for a specific therapeutic purpose as it allows researchers to narrow down the number of candidates by assessing ...

A new method of CAR T-cell immunotherapy developed by researchers at the University of Pennsylvania Perelman School of Medicine could serve as a treatment for most blood cancers. Until now, CAR ...