The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Using powerful new visualization technologies, researchers have captured the first 3-D images of the structure of a key muscle receptor, providing new insights on how muscles develop across the animal ...

“This article illuminates the biology behind EDG-5506, demonstrating that modulation of fast skeletal muscle contraction protects against muscle injury, degeneration and fibrosis in models of DMD,” ...

The first comprehensive cell atlas of aging human muscle reveals the intricate genetic and cellular processes behind muscle deterioration and mechanisms to counteract it. How muscle changes with ...

The connections between the nervous system and muscles develop differently across the kingdom of life. It takes newborn humans roughly a year to develop the proper muscular systems that support the ...

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Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...

Muscles are made up of proteins. Myosin, a fibrous protein, serves as a molecular motor and converts the chemical energy stored inside our body into mechanical energy. The synergistic association ...

In a serendipitous discovery, UC San Diego researchers using cryo-EM technology captured the first visualizations of the 3-D structure of the muscle acetylcholine receptor in fetal and adult muscles.