The study, published in Genomic Psychiatry, identified how stress hormones activate specific RNA molecules called long ...
Abstract HighlightsORIC-944 is a potent, highly selective, orally bioavailable, allosteric inhibitor of PRC2 that demonstrates best-in-class drug properties, including potency, solubility, and ...
New research led by Professor Yogesh Dwivedi at the University of Alabama at Birmingham uncovers how long noncoding RNAs engage chromatin-silencing machinery under glucocorticoid receptor activation, ...
Epigenetics, the dynamic regulation of genetic expression, involves complex molecular mechanisms. While the process of gene silencing by methylating the H3K27 position in histones is understood, not ...
Dysregulation of the polycomb repressive complex 2 (PRC2) is associated with epigenetic silencing of tumor suppressor genes, leading to alterations in cell proliferation, differentiation and survival ...
Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with ...
Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with ...
Changes in histone modifications of genes involved in flowering. (a) The removal of Polycomb complexes by SDG7 protein. (b) Transcription elongation and the deposition of H3K36me3 by SDG8 protein. PRE ...
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