DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that aid DNA in carrying out essential processes such as replication, repair, and ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a ...

Researchers show that loss of the SPRTN enzyme lets DNA–protein crosslinks accumulate, leak DNA into the cytoplasm, activate ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...