Sequence analysis is a cornerstone of modern bioinformatics, encompassing the computational exploration of biological sequences—be they DNA, RNA or proteins—to reveal insights into structure, function ...

What is Third-Generation Sequencing? Third-generation sequencing, also known as long-read sequencing, refers to the latest advancements in DNA sequencing technologies that enable the analysis of ...

Historical introduction and overview -- Collecting and storing sequences in the laboratory -- Alignment of pairs of sequences -- Introduction to probability and statistical analysis of sequence ...

Diagram of the haplotype-aware transcriptome analysis pipeline. Analyzing a person’s gene expression requires mapping their RNA landscape to a standard reference to gain insight into the degree to ...

Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...