New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example, DNA damage ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Cells are not immortal, and that is a good thing. After a certain number of divisions, many human cells stop multiplying for ...

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres—the protective ...

A new study demonstrates that replicative senescence depends upon ATM kinase, and that high oxygen generates a hyperactive ...