The FDA is weighing the regulatory fate of KarXT — an oral dual M1/M4 muscarinic acetylcholine receptor (mAChR) agonist — for schizophrenia. If approved, the fixed-dose combination of xanomeline and ...

The human P2X4 receptor plays an important role in chronic pain, inflammation and some types of cancer. Researchers at the ...

Humans have bitter taste receptors not only in their mouths but in their lungs, too. Researchers have exploited these receptors’ innate ability to dilate the airways to create a potent new drug that ...

New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung ...

The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus has a high transmission rate, and its symptoms may ...

Many breast cancer drugs block estrogen receptors inside cancer cells. Blocking the receptors early in disease progression staves off metastasis. But most patients with advanced disease eventually ...

A team of researchers have used high-powered microscopes to view serotonin activating its receptor for the first time. Images reveal molecular details about the receptor that could improve drug design ...

Image of a cortical neuron (white) expressing serotonin 2A (5-HT2A) receptors (multicolor). New work shows that engaging 5-HT2A receptors inside cells, but not on the cell surface, encourages cell ...

A drug that is already clinically available for the treatment of nausea and psychosis, called prochlorperazine (PCZ), inhibits the internalization of receptors on the surface of tumor cells, thereby ...

Scientists are testing whether GLP-1 drugs can help to cut cravings for cigarettes, alcohol and opioids — as well as food.

A drug that targets the coronavirus’ entry point into cells could protect against the infection as new variants emerge. Existing treatments and vaccines work against SARS-CoV-2 itself, raising the ...

The explosive rise of drugs like Ozempic and Mounjaro is shifting consumption patterns, health outcomes and pushing ...