Due to its high accuracy and fast, simple workflow, capillary electrophoresis (CE) is a foundational technology for clinical applications. CE is an invaluable tool used to detect genetic variations ...

The first DNA sequencing method was developed by Frederick Sanger in 1977. The technique was based on incorporation of chain-terminating dideoxynucleotides by DNA polymerase while replicating DNA. So ...

Sanger sequencing is a DNA sequencing method developed by Fred Sanger in 1977. The technique is based on incorporation of chain-terminating dideoxynucleotides by DNA polymerase during replication of ...

In 1997, Sanger, Nicklen and Coulson described a method for determining DNA nucleotide sequences. 1 Nearly five decades later, Sanger sequencing remains an entrenched technology for targeted ...

DNA sequencing is a powerful technique firmly entrenched into every aspect of biological research and drug discovery. Recent advances in high throughput capillary sequencing combined with the shotgun ...

When DNA sequencing first broke onto the scene in the 1970s, one method shone brighter than even Sanger sequencing. However, this method is now almost obsolete. What was it and what happened to it? In ...