High-intensity focused ultrasound (HIFU) is an increasingly used, locally ablative therapy option in localized prostate cancer (PCa). Multiparametric MRI (mpMRI) is currently used for tumor ...

Nuclear medicine has undergone a remarkable transformation, with both diagnostic and therapeutic applications expanding at an unprecedented pace. This progress is rooted in fundamental discoveries by ...

Radiotheranostics refers to dual diagnostic–therapeutic capacity that allows for precision medicine at an unprecedented level, reducing collateral toxicity and improving patient outcomes ([1][1]). In ...

Molecular imaging and targeted radiotherapy with radiolabeled cholecystokinin-2 receptor (CCK2R) targeting peptide probes holds high promise to improve the clinical management of patients with ...

Journal of Nuclear Medicine November 2025, jnumed.125.270568; DOI: https://doi.org/10.2967/jnumed.125.270568 ...

Aptamers, single-stranded oligonucleotides, are an important class of molecular targeting ligand. Since their discovery, aptamers have been rapidly translated into clinical practice. They have been ...

The field of theranostics dates back over 80 y, when Hertz and Roberts first used radioactive iodine to treat thyroid disease. Recent theranostic approvals for neuroendocrine tumors and prostate ...

Journal of Nuclear Medicine November 2025, jnumed.125.270404; DOI: https://doi.org/10.2967/jnumed.125.270404 ...

Quantitative 18F-FDG PET is increasingly being recognized as an important tool for diagnosis, determination of prognosis, and response monitoring in oncology. However, PET quantification with, for ...

18 F-FDG PET Reveals Voxel-Based Decreases in Brain Glucose Uptake After Chemotherapy in Leukemia Patients: A Retrospective Matched-Control Study ...

Lewy body diseases (LBDs) feature profound myocardial depletion of the sympathetic neurotransmitter norepinephrine. In addition to sympathetic neuronal loss, the norepinephrine deficiency may reflect ...

For staging of cancer patients, 18F-FDG PET imaging has been applied for about a decade. It is generally accepted that imaging the metabolic activity of tumor tissue provides more sensitive and more ...