Tennessee Titans defensive tackle Jeffery Simmons is dealing with a lot of ups and downs after the team's Week 15 loss against the San Francisco 49ers. Simmons

The San Francisco 49ers defeated the Tennessee Titans on Sunday. Here's who had the best and worst days, according to Pro Football Focus.

Tennessee Titans star Jeffery Simmons' Nashville home was burglarized by "at least six suspects" while he played against the 49ers, sparking an angry response.

The final whistle on the 2025 NFL season will be blown before we know it so we have to take advantage of the final few weeks as fans and bettors. One of the way

The Tennessee Titans couldn't keep up with the methodical, forward-moving offense of the San Francisco 49ers, dropping the Titans in the loss column.

Ricky Pearsall is facing another injury setback. He had six catches for 96 yards on Sunday, helping the San Francisco 49ers beat the Tennessee Titans 37-24.

Lines are typically sharp this deep into the season, but injuries and quarterback changes can shake things up a lot. There has been some notable NFL line movement in Week 16. Here, we will break down the games that have seen the biggest shifts since lines first opened, with all odds courtesy of DraftKings Sportsbook.

The Tennessee Titans placed three safeties on injured reserve after their Week 15 loss to the 49ers, forcing emergency roster moves.

USA Today's NFL experts make their picks for a Week 16 showdown between the Tennessee Titans and Kansas City Chiefs

The Tennessee Titans have eight picks in the 2026 NFL Draft. Here are The Tennessean's too-early projections for how to build around Cam Ward.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.