Cancer isn't just about broken genes-it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services.

Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

Amyotrophic lateral sclerosis (ALS) affects nerve cells in the brain and spinal cord. The authors' approach to use genetic code expansion to tag two ALS proteins associated with stress granules has ...

An investigation into cellular components in bacteria has unexpectedly uncovered a feature with relevance across many life ...

Cancer involves more than just genetic mutations; it also involves structural failures. Consider a city where roads disappear ...

ASH 2025 research shows cancer can arise not just from mutations but from broken DNA architecture. AI reveals how lost genome loops silence tumor suppressor genes.

Cancer isn't just about broken genes—it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off ...

Researchers found that DNA's shape matters. When its loops break, cancer can start.Based on a new concept of architectural tumor ...

EMBARGOED: A new study to be presented Dec. 6 at the 2025 American Society of Hematology (ASH) meeting reveals that even subtle disruptions in genome architecture can predispose individuals to ...

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...