DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...
A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...
Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...
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A single protein decides when human cells grow old, study finds
Cells are not immortal, and that is a good thing. After a certain number of divisions, many human cells stop multiplying for ...
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Mitotic stopwatch pathway shows how cancer loses its sense of time to avoid stress responses
When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example, DNA damage ...
Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...
After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres—the protective ...
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