Mitochondrial enzyme's atomic-level structure reveals how it processes RNA

Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...
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Visualizing the Fundamental Process of DNA Strand Separation

For the first time, scientists have captured the exact moment DNA begins to unravel, shedding light on a fundamental chemical process that enables DNA to serve as the blueprint for life. A recent ...

First human DNA-cutting enzyme that senses physical tension discovered

An international research team has identified a human protein, ANKLE1, as the first DNA-cutting enzyme (nuclease) in mammals ...

New Discovery Exposes the Hidden Weak Spot Cancer Uses to Survive DNA Damage

Scripps Research scientists have discovered how some tumors endure DNA damage, revealing a potential new way to target them. The DNA inside our cells is constantly exposed to damage, and one of the ...
Science Daily

Scientists capture most detailed look inside DNA droplets

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...
eLife

Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...