RFdiffusion2, RFdiffusion3, and Riff-Diff each solve different structural problems in computational enzyme design ...

For the first time, scientists have captured the exact moment DNA begins to unravel, shedding light on a fundamental chemical process that enables DNA to serve as the blueprint for life. A recent ...

Amyotrophic lateral sclerosis (ALS) affects nerve cells in the brain and spinal cord. The authors' approach to use genetic code expansion to tag two ALS proteins associated with stress granules has ...

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...

Inside every human cell, six feet of DNA folds into a nucleus that is only a few micrometers wide, yet still manages to ...

This toxin, called colibactin, is made by certain strains of E. coli and other microbes that naturally live in the human gut.

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable ...

The microbe Pyrodictium abyssi is an archaeon—a member of what's known as the third domain of life—and an extremophile. It ...

After two decades in the making, scientists have cracked the code on a drug that can repair DNA, setting the scene for a new ...

Scientists capture the most detailed 3D images of chromatin condensates, revealing how DNA packs tightly inside cells.

When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key ...

For the first time, chemists have fully synthesized verticillin A, a notoriously complex fungal molecule with striking anticancer potential.