san francisco 49ers nfl

NFL, San Francisco 49ers and Titans

49ers vs Colts picks, predictions, odds for NFL Week 16 game Monday

The San Francisco 49ers and Indianapolis Colts play on Monday, Dec. 22, at the Colts' Lucas Oil Stadium in a game on the NFL Week 16 schedule.

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49ers vs. Titans: Where to watch NFL Week 15, betting odds, score prediction, sportsbook promos, SGP picks

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What channel is 49ers vs Titans NFL game today? Start time, schedule, where to watch, streaming

Niners Wire · 23h

Best photos from 49ers vs. Titans in Week 15

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) warms up prior to the first half against the Tennessee Titans at Levi's Stadium.

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Titans vs 49ers injury updates: Inactives mean bad news for QB Cam Ward

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Titans' Jeffery Simmons records a sack, forced fumble and a TD catch in loss to 49ers

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How PFF graded Brock Purdy, 49ers' position groups in Week 15 win over Titans

The offensive line gave quarterback Brock Purdy an average of 3.44 seconds to throw, the highest since Week 5 of the 2024 season.

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Titans' losing ways return as Cam Ward can't keep up with high-flying 49ers

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Titans cannot keep up with Brock Purdy, 49ers offense in 37-24 loss

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NFL Week 16 Survivor Pool Picks (49ers, NFC South Squad Highlight Top Predictions)

Only three weeks are left in the NFL regular season, and if you’re still fighting out in Survivor, we wish you the best of luck. Week 16 features a full 16-gam

16hon MSN

NFL injury report, update: San Francisco 49ers vs Indianapolis Colts for NFL Week 16

The Indianapolis Colts host the San Francisco 49ers on " Monday Night Football " in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games.

How 49ers have positioned themselves for deep NFL playoff run despite adversity

Although nothing seems to have gone well for the 49ers this season, San Francisco still is in good shape to make a run in the 2025 NFL playoffs.

59mon MSN

Titans' Jeffery Simmons Talks Touchdown vs. 49ers

Tennessee Titans defensive tackle Jeffery Simmons is dealing with a lot of ups and downs after the team's Week 15 loss against the San Francisco 49ers. Simmons

49ers Webzone

49ers in Week 15 power rankings: Where San Francisco stands after the bye week

See where the San Francisco 49ers stand in Week 15 power rankings as the team comes off its bye week, riding a three-game win streak.

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NFL playoff picture: What 49ers’ win over Titans means for NFC standings

The 49ers face the Titans at home in Santa Clara in Week 15. We break down what the game means for the NFL playoff picture.

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San Francisco 49ers end Brandon Aiyuk's season in roster move

Brandon Aiyuk hasn't played an NFL game since his serious knee injury in 2024. Here's why he won't be playing at all in 2025.

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49ers’ Kyle Shanahan Reveals Concerning News After Critical Win

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.