AIM To compare the efficacy and safety of an indomethacin treatment strategy based on serial echocardiographic measurement of patent ductus arteriosus (PDA) flow pattern with a standard protocol.

3 Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK 4 Centre For Paediatrics, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary ...

2 College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK 3 Health and Human Sciences, University of Westminster, London, UK Objectives To investigate the ...

Healthcare decisions should be based on all relevant evidence.1 Usually, this is provided by randomised controlled trials (RCTs) comparing two or more interventions for a condition affecting a target ...

Cytomegalovirus (CMV) is a common pathogen, associated with mild illness in most immunocompetent people. Historically, research on CMV infection in the relatively immunocompromised premature and small ...

Background Progressive ventricular dilatation after intraventricular haemorrhage (IVH) in preterm infants has a very high risk of severe disability and death. Drainage, irrigation and fibrinolytic ...

Correspondence to Dr Martin Ward Platt, Newcastle Neonatal Service, Ward 35, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK; m.p.ward-platt{at}ncl.ac.uk If you wish to ...

Correspondence to: Dr Roberts, Department of Haematology, Hammersmith Campus, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; irene.roberts{at}ic.ac.uk Neonatal thrombocytopenia is a common ...

Department of Paediatrics, Level 6, Clinical Science Building, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong, Peoples Republic of China ...

Objective The Canadian Congenital Diaphragmatic Hernia (CDH) Collaborative sought to make its existing clinical practice guideline, published in 2018, into a ‘living document’. Design and main outcome ...

Background Ketones and lactate may contribute towards overall cerebral fuel availability in term infants, yet the availability of such cerebral fuels in very preterm infants is unclear. We undertook a ...

The management of low blood flow states in premature neonates is fraught with many challenges. We remain over-reliant on regimented stepwise protocols that use mean blood pressure as a threshold for ...