The EMBO Journal

Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction

While whole genome sequencing (WGS) of cell-free DNA (cfDNA) holds enormous promise for detection of molecular residual disease (MRD), its performance is limited by ...
The EMBO Journal

Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The viral M45 protein forms functional amyloid ...
The EMBO Journal

Interrogation of RNA-protein interaction dynamics in bacterial growth

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Characterising RNA–protein interaction ...
The EMBO Journal

HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Corneal diseases can cause severe visual ...
The EMBO Journal

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C‐terminally truncated catalytic and two regulatory subunits has been determined at 3.1 Å ...
The EMBO Journal

MHC class II molecules on the move for successful antigen presentation

Major histocompatibility complex class II (MHC II) molecules are targeted to endocytic compartments, known as MIIC, by the invariant chain (Ii) that is degraded upon arrival in these compartments. MHC ...
The EMBO Journal

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation. HMGB1 can also be secreted by activated monocytes and macrophages, and ...
The EMBO Journal

Scientific Skills Workshops

In this workshop we work on the principles, practicalities and strategies of writing a scientific research article. Topics covered include understanding the structure and content of a manuscript, ...
EMBO Press

Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice

Isomeranzin (ISM) binds to Gnas, activating adenylyl cyclase and elevating intracellular cAMP levels. This activation triggers the AMPK pathway, upregulating thermogenic genes such as Pgc1α and Ucp1.
EMBO Press

Dynamics of checkpoint receptors in γδ T cell subsets are associated with clinical response during anti-PD-1 immunotherapies

Different subsets of γδ T cells display differential expression of immune checkpoint receptors (ICRs) and have distinct biological characteristics that are associated with cancer and the efficacy of ...
EMBO Press

Withdrawal Note: KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination

Figure 6C, the same pictures were used for different genotypes, i.e. kno1 RMI1-RFP and agt5 RMI1-RFP; the pictures are magnifications from the time course in EV5, which represents atg5 RMI1-RFP. Note ...
The EMBO Journal

Selective cross‐linking of coinciding protein assemblies by in‐gel cross‐linking mass spectrometry

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cross‐linking mass spectrometry has developed ...