Defeating the Tennessee Titans didn't prove to be too difficult for the San Francisco 49ers. That much was expected going into it. Although it did start to get

San Francisco 49ers quarterback Brock Purdy (13) runs the ball past Tennessee Titans linebacker Cedric Gray, left, during the second half of an NFL football game, Sunday, Dec. 14, 2025, in Santa Clara, Calif. Credit: AP/Godofredo A. Vásquez

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team's fourth win in

The defense. The Titans lost a trio of safeties to injuries after a couple of series. They also allowed seven straight third-down conversions. Tennessee gave up points on the 49ers' first five possessions — four of them touchdowns. The Titans didn't force a single punt.

The Tennessee Titans had no answer for Brock Purdy and the San Francisco offense in a Week 15, 37-24, loss to the 49ers .

The Tennessee Titans and the San Francisco 49ers meet Sunday in Week 15 in Santa Clara, California, with kickoff slated for 4:25 p.m. ET.

The Tennessee Titans say the home of defensive tackle Jeffery Simmons was burglarized while he was on the road in San Francisco.

The Titans Wire staff offer their picks and predictions ahead of a Week 15 game between the Tennessee Titans and San Francisco 49ers.