Mitochondrial enzyme's atomic-level structure reveals how it processes RNA

Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

First human DNA-cutting enzyme that senses physical tension discovered

An international research team has identified a human protein, ANKLE1, as the first DNA-cutting enzyme (nuclease) in mammals ...

New Discovery Exposes the Hidden Weak Spot Cancer Uses to Survive DNA Damage

Scripps Research scientists have discovered how some tumors endure DNA damage, revealing a potential new way to target them. The DNA inside our cells is constantly exposed to damage, and one of the ...
Nature

‘Giant step forward’ for Huntington’s — the scientist behind the first gene therapy

On a video call in early September, Sarah Tabrizi first saw the data that she and other researchers studying Huntington’s ...
Nature

The baby whose life was saved by the first personalized CRISPR therapy

To the research team working to save him, KJ Muldoon was first known only as Patient Eta. But within months, KJ’s name — and ...
Science Daily

Scientists capture most detailed look inside DNA droplets

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...