For a cell to progress through the G1 phase of the cell cycle and divide, it must first integrate various signals. It emerges that cells in a ‘primed’ G1 state — characterized by intermediate ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...