CDT1 overexpression suppresses DNA replication and triggers DNA damage linked to cancer, finds study

A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...
EurekAlert!

CDT1 overexpression suppresses DNA replication and induces DNA damage, suggesting a mechanism for cancer development

A research group led by Drs. Shusuke Tada and Takashi Tsuyama at the Department of Molecular Biology, Faculty of ...

Newly Discovered DNA “Danger Zone” Could Change What We Know About Human Disease

A new study reports that the locations where genes begin are particularly prone to mutations, and these genetic changes can ...
News-Medical.Net

Scientists uncover why SETX-deficient cancer cells rely on error-prone DNA repair

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break-when both sides of the DNA helix are cut at once.
AZoLifeSciences on MSN

Study uncovers principles guiding replication initiation across the human genome

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...
eLife

Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...
News-Medical.Net

New method reveals how human cells initiate DNA replication

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...