The FDA is weighing the regulatory fate of KarXT — an oral dual M1/M4 muscarinic acetylcholine receptor (mAChR) agonist — for schizophrenia. If approved, the fixed-dose combination of xanomeline and ...
G protein-coupled receptors (GPCRs) represent the largest family of membrane proteins and one of the most successful therapeutic targets in modern medicine, with approximately 34% of FDA-approved ...
Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...
Many breast cancer drugs block estrogen receptors inside cancer cells. Blocking the receptors early in disease progression staves off metastasis. But most patients with advanced disease eventually ...
New psychoactive substances, originally developed as potential analgesics but abandoned due to adverse side effects, may ...
Researchers at Karolinska Institutet in Sweden and the RIKEN Center for Brain Science in Japan have identified two receptors ...
Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...
Amylin, a hormone that controls appetite and blood sugar by activating three different receptors in the brain, could be the basis for the next blockbuster obesity drugs. A University of Oklahoma study ...
Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...
For years, people taking one of the world’s most common heart drugs have described the same nagging side effect: sore, aching ...
Oct. 28 -- TUESDAY, Oct. 27 (HealthDay News) -- Some common herbicides and cholesterol drugs block a nutrient-sensing receptor known as T1R3, researchers report. "Compounds that either activate or ...