RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function ...

High-resolution structures explain the mechanism of human PNPase and provide insights into mutations causing hereditary ...

A new RNA type, smOOPs, has been found to drive biomolecular condensate formation in early development, offering new insight ...

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer ...

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing ...

A Northwestern Medicine study published in the Journal of Clinical Investigation has uncovered a connection between a ...

Researchers have used cryo-EM and computational tools to visualize ribozyme assembly, shedding light on life's most versatile ...

Spatial RNA medicine combines transcriptomics and RNA therapeutics, mapping gene expression in tissues to enhance precision ...

When MIT neurobiologists tracked how more than 200 motor neurons in fruit flies each edited their RNA, they cataloged hundreds of target sites and widely varying editing rates. Scores of edits altered ...

Preclinical in vivo data demonstrate hyper-precise mechanism directly targets the disease-causing mRNA repeats leading to correction of splicing ...