The polypyrimidine tract binding protein (PTB) binds pre-mRNAs to alter splice-site choice. We characterized a series of spliceosomal complexes that assemble on a pre-mRNA under conditions of either ...

Protein-degrader structure and function have been captured in unprecedented detail. Protein degraders are recognized as an exciting avenue for drug discovery and development, providing targeted ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 24 (June 12, 2012), pp. 9420-9425 (6 pages) Protein domains are conspicuous structural units in globular ...

Protein is one of the three macronutrients, along with fat and carbohydrate. These are essential for the optimal functioning of the body. However, too much protein — especially with no fat or carbs — ...

Recently identified and long-lasting type of protein misfolding — non-native entanglements — observed in all-atom protein folding simulations. Representative misfolded conformations of the small ...

Protein isn't just for gym bros looking for ridiculous gains—it’s key to your overall health. Experts say that if you skimp ...

From muscle growth to cellular repair, proteins fuel everything in the body. However, not all proteins are created equal. The debate between animal and plant protein has long been going on. Well, it ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints ...