Enzymes that cut DNA at specific sites are called endonucleases; these enzymes play many roles in genomic replication, fidelity, and defense. The initial discovery of restriction endonucleases in the ...

Homologous recombination is an ancient process that functions to conserve genetic integrity and create genetic diversity. It relies on the formation of Holliday junctions — four-stranded DNA ...

In the early 1950s, experiments by two teams of researchers, Salvador Luria working with Mary Human and Joe Bertani working with Jean Weigle, showed that some strains of bacteria were more resistant ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 17 (Aug. 17, 1999), pp. 9757-9762 (6 pages) ClpXP-dependent proteolysis has been implicated in the delayed ...

To many working biologists, DNA-modifying enzymes are tools, not unlike a pair of molecule-sized scissors. To Dr. Barry Stoddard, a professor in the Basic Sciences division at Fred Hutch, these ...