RMD Open

Early-life animal and farming exposures and the risk of rheumatoid arthritis: findings from the E3N French cohort study

Objective The objective of this study is to assess the association between childhood exposure to pets and farm animals and ...
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Efficacy of ozoralizumab in rheumatoid arthritis patients with large joint involvement: a post hoc analysis of OHZORA and NATSUZORA trials

Objectives To compare the efficacy of ozoralizumab in patients with rheumatoid arthritis (RA), with or without large joint involvement (LJI). Methods A post hoc analysis was conducted for Japanese ...
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Sex and reproductive stage modify the effect of endogenous oestrogens on coronary atherosclerosis in rheumatoid arthritis

Objective We explored associations between endogenous oestrogens, coronary atherosclerosis and cardiovascular risk in rheumatoid arthritis (RA). We interrogated whether these relationships varied by ...
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Long-term outcomes of JIA-associated uveitis: a systematic review and meta-analysis

Background and aim Juvenile idiopathic arthritis-associated uveitis (JIAU) is a potentially blinding condition beginning in childhood. Flare-ups may occur throughout life, leading to cumulative ocular ...
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Sustained improvements in spinal pain, morning stiffness, fatigue, sleep, physical function and overall health-related quality of life with bimekizumab in patients with axial ...

Objective To assess the long-term effect of bimekizumab, a dual inhibitor of IL-17A and IL-17F, on patient-reported symptoms, function and health-related quality of life (HRQoL) in patients with axial ...
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Upadacitinib in patients with psoriatic arthritis and an inadequate response to non-biological therapy: 56-week data from the phase 3 SELECT-PsA 1 study

Background In SELECT-PsA 1, a randomised double-blind phase 3 study, upadacitinib 15 mg and 30 mg were superior to placebo and non-inferior to adalimumab in ≥20% improvement in American College of ...
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Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis

Objectives Long-term outcomes in rheumatoid arthritis (RA) depend on early and effective disease control. Methotrexate (MTX) remains the first-line disease modifying therapy, however there are no ...
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Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT

Objective To investigate complement system activation and complement protein levels in relation to radiographic progression in axial spondyloarthritis (axSpA) within a longitudinal randomised ...
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Identification of individuals at high risk of developing rheumatoid arthritis: a balanced random forest model in a cohort of 1544 first-degree relatives

Objectives To identify in a genetically susceptible population individuals at higher risk of developing rheumatoid arthritis (RA) using a classification approach combining known epidemiological risk ...
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Automated ultrasound in rheumatology: the dawn of a new era

Diagnosis made with an imaging technique is the result of two mainly sequential, variously and closely intertwined processes: image acquisition and image interpretation. These two processes may be ...
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Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease

Objectives Activated synovial fibroblasts play a key role in rheumatoid arthritis (RA). Positron emission tomography-CT (PET-CT) using 68g allium-labelled fibroblast activation protein inhibitor (FAPI ...