Thorax

Blood eosinophil-guided systemic corticosteroid duration in adults hospitalised for asthma exacerbation: a randomised, controlled, open-label, non-inferiority trial

Objective Systemic corticosteroids for 5–7 days are standard care for asthma exacerbations, but the optimal duration and ...
Thorax

Maternal eating disorders and respiratory outcomes in childhood: findings from the EU Child Cohort Network

Background While maternal depression and anxiety have been linked to adverse childhood respiratory outcomes, the role of ...
Thorax

Predictive capacity of paediatric nasal epithelial cells in sequential CFTR modulator therapy

Background CFTR modulators have transformed cystic fibrosis (CF) treatment, but individual responses vary even among patients with identical CFTR genotypes. This underscores the need for predictive ...
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Shape-sensing robotic-assisted bronchoscopy with integrated mobile cone-beam CT for small nodules: results from the prospective multicentre CONFIRM study

Background The use of 3D imaging with navigation bronchoscopy has increased with the introduction of mobile cone-beam CT (mCBCT). Shape-sensing robotic-assisted bronchoscopy (ssRAB) integrated with ...
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Comparative safety of inhaled medications in patients with chronic obstructive pulmonary disease: systematic review and mixed treatment comparison meta-analysis of randomised ...

3 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Correspondence to Dr Mei-Shu Lai, Graduate Institute of Epidemiology and Preventive Medicine, College of Public ...
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Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema

1 Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA 2 Divison of General Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA 3 Department ...
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Systemic inflammation and comorbidity in COPD: a result of ‘overspill’ of inflammatory mediators from the lungs? Review of the evidence

Correspondence to Robert A Stockley, Lung Investigation Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK; rob.stockley{at}uhb.nhs.uk Chronic obstructive pulmonary disease (COPD) is ...
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Risk factors for community-acquired pneumonia in adults in Europe: a literature review

Background Community-acquired pneumonia (CAP) causes considerable morbidity and mortality in adults, particularly in the elderly. Methods Structured searches of PubMed were conducted to identify up-to ...
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Frequency and severity of respiratory infections prior to COPD diagnosis and risk of subsequent postdiagnosis COPD exacerbations and mortality: EXACOS-UK health care data study

Objective Little is known about how lower respiratory tract infections (LRTIs) before chronic obstructive pulmonary disease (COPD) are associated with future exacerbations and mortality. We ...
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Risk of hospital admission for COPD following smoking cessation and reduction: a Danish population study

1 The Copenhagen Centre for Prospective Population Studies, Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Copenhagen University Hospital, Denmark 2 Department of ...
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Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC)

Background: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence and severity of asthma symptoms in children. Methods: A cross-sectional ...
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Mucus clears from the trachea in a helix: a new twist to understanding airway diseases

Background Mucociliary clearance (MCC) is critical to lung health and is impaired in many diseases. The path of MCC may have an important impact on clearance but has never been rigorously studied. The ...